I-94 (Ford Freeway)
From Detroit (heading West)

Take I-94 West to US-23 North Exit 180. Take Exit 41 (Plymouth Road). At the end of the exit, take a left (west) onto Plymouth Rd. Go approximately two miles and take a left on Murfin Road. You can either continue on Murfin to Pierpont Commons (on your left, before Bonisteel Boulevard) and park in the lot there or take Murfin to Bonisteel and turn left onto it. At the next left where Beal and Bonisteel meet there is a parking lot on your left.

I-94 (Ford Freeway)
From Chicago (heading East)

(Easiest way for directions, but also longest) Take I-94 East to US-23 North Exit 180. Take Exit 41 (Plymouth Road). At the end of the exit, take a left (west) onto Plymouth Rd. Go approximately two miles and take a left on Murfin Road. You can either continue on Murfin to Pierpont Commons (on your left, before Bonisteel Boulevard) and park in the lot there or take Murfin to Bonisteel and turn left onto it. At the next left where Beal and Bonisteel meet there is a parking lot on your left.

or

Take I-94 East to M 14 East (towards Plymouth) to US 23 South. Take Exit 41 (Plymouth Road). At the end of the exit take a left (west) onto Plymouth Rd. Go approximately two miles and take a left on Murfin Road. You can either continue on Murfin to Pierpont Commons (on your left, before Bonisteel Boulevard) and park in the lot there or take Murfin to Bonisteel and turn left onto it. At the next left where Beal and Bonisteel meet there is a parking lot on your left.

US-23
From Ohio (heading North)

Take 23 North to Exit 41 (Plymouth Road). Turn left (west) off the exit onto Plymouth Rd. Go approximately two miles and take a left on Murfin Road. You can either continue on Murfin to Pierpont Commons (on your left, before Bonisteel Boulevard) and park in the lot there or take Murfin to Bonisteel and turn left onto it. At the next left where Beal and Bonisteel meet there is a parking lot on your left.

US-23
From Northern MI (heading South)

Take 23 South to Exit 41 (Plymouth Road). Turn right (west) off the exit onto Plymouth. Go approximately two miles and take a left on Murfin Road. You can either continue on Murfin to Pierpont Commons (on your left, before Bonisteel Boulevard) and park in the lot there or take Murfin to Bonisteel and turn left onto it. At the next left where Beal and Bonisteel meet there is a parking lot on your left.

I-696 (W.P. Ruether Freeway)
From Northwest Suburbs

Take I-696 West to I-275 South to M-14 West to US-23 South. Take Exit 41 (Plymouth Road). Turn right (west) off the exit onto Plymouth Road Go approximately two miles and take a left on Murfin Road. You can either continue on Murfin to Pierpont Commons (on your left, before Bonisteel Boulevard) and park in the lot there or take Murfin to Bonisteel and turn left onto it. At the next left where Beal and Bonisteel meet there is a parking lot on your left.

I-96 (also called the Jeffries Freeway)
From Parts of Detroit, Redford, M-14, Plymouth and Canton

Take I 96 to M 14 west to US 23 South (Exit 42). Take Exit 41 (Plymouth Road). Turn right (west) off the exit onto Plymouth Road. Go approximately two miles and take a left on Murfin Road. You can either continue on Murfin to Pierpont Commons (on your left, before Bonisteel Boulevard) and park in the lot there or take Murfin to Bonisteel and turn left onto it. At the next left where Beal and Bonisteel meet there is a parking lot on your left.

(Shamelessly borrowed from the U-M web site, because they force it to pop-up in a new framed window)